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Importantly, the therapeutic content appeared to play a decisive role: studies targeting memory and executive functions showed more robust benefits than those focused on general cognitive stimulation or attention alone

Table 1 displays the primer sequences of target genes using the housekeeping gene -actin as internal control along with the amplified PCR product sizes

In conclusion, MS involves complex metabolic alterations in T cells, with enhanced glycolysis and disrupted lipid metabolism contributing to Th17/Treg imbalance, while microbial metabolites and fatty acids offer promising therapeutic avenues for immune resetting

doi: 10.1016/j.brs.2017.10.006 108