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Genomics 5:83

58 The decrease in autophagy in aged HSCs leads to the accumulation of active and healthy mitochondria and increased metabolism, particularly increased oxidative phosphorylation, promoting accelerated myeloid differentiation of HSCs

demonstrated that FK228, an HDAC inhibitor, induces histone hyperacetylation in synovial cells, leading to reduced levels of tumour necrosis factor (TNF-) and interleukin-1 (IL-1) and the inhibition of vascular endothelial growth factor production [34]

Selenocysteine was the first noncanonical amino acid discovered outside the original 20 amino acids of the genetic code (Cone et al