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Considering the important role of the above aspects in PNI, it is feasible to explore the mechanism of PNI by studying the interaction between cancer cells and nerves, the expression of neurotrophic factors, and the invasion and migration ability of cancer cells in the process of PNI

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when the intestine is inflamed and neutrophils are present, lactoferrin levels increase in the lumen and stool [42][45]

Many studies involving vitamin B12 have been conducted in combination with other B-complex vitamins, yielding more pronounced beneficial effects