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Zastosowanie systemowe (rekonstytucja) vs topiczne (formulacja z baz kremow)

10.1038/ncomms11312 104 Keren-ShaulH.SpinradA.WeinerA.Matcovitch-NatanO.Dvir-SzternfeldR.UllandT

The high failure rates of experimental drugs in late-stage clinical trials highlight a disconnect between preclinical findings and human studies, largely due to inadequate disease models that fail to capture the full complexity of human AD pathology ( in vitro and in vivo studies showing their efficacy in reducing oxidative stress, neuroinflammation, and A accumulation (Mohamed Yusof and Mohd Fauzi 2024)

Stable between pH 57 with proper chelation and oxygen control