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PCAF-mediated acetylation of LDHB at K82 was found to significantly decrease its enzymatic activity and impair hepatic lactate clearance, resulting in lactate accumulation, which exacerbates lipid deposition and inflammatory responses by activating histone hyperacetylation in high-fat diet (HFD)-induced NAFLD

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CD4 + , CD8 + , and T cells drive inflammation and activate HSCs, which in turn regulate T cell differentiation and proliferation

Antioxid Redox Signal 27:11271129 Townsend DM, Tew KD, Tapiero H (2003) The importance of glutathione in human disease