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Both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have issued strict guidelines for immunogenicity assessment, which are highly relevant to the development of peptide-based alopecia treatments [124]

These findings have not been limited to the liver, but also to other organs such as the heart and the brain

In response to the inflammatory mediator, the atherosclerosis lesion may be heavily infiltrated with pro-inflammation cells, including macrophages, T cells and neutrophils (49), and the lesion size began to enlarge (50)