oxidative damage can be repaired by glutathione Apoptosis and glutathione: beyond an antioxidant The antioxidant glutathione - ScienceDirect

In conclusion, this work offers a new view that foods rich in kaempferol may possess a healthy benefit for the prevention of colitis

Comparative Antioxidant Profiles Property Glutathione (GSH) Ergothioneine (EGT) Redox activity Very high, dynamic Moderate, stable Chemical stability Low (constantly recycled) Very high Specific transporter No Yes (OCTN1/SLC22A4) Tissue accumulation Limited High (brain, liver, eyes) Mitochondrial protection Indirect (via GPx) Direct DNA protection Mitochondrial (primary) Nuclear and mitochondrial Intestinal degradation Partial Very low Human synthesis Yes (liver) No (dietary only) Mushrooms as the Only Known Source of Both Molecules While glutathione is also found in other foods asparagus, avocado, red meat ergothioneine is found almost exclusively in mushrooms

Twenty-five metabolite sets demonstrated enrichment, with the most prominent pathways including arginine and proline metabolism, glutathione metabolism, D-amino acid metabolism, glycine, serine and threonine metabolism, and beta-alanine metabolism

Postuma et al., 2015)