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One of the important pathways of peroxynitrite-mediated vascular dysfunction in diabetes involves activation of the nuclear enzyme poly(ADP-ribose) polymerases (PARP enzymes)

In both salivary glands we observed reduced activity of cytochrome c oxidase, NADPH oxidase, and xanthine oxidase, as well as hindered production of ROS and lower ADP/ATP radio, but the levels of these parameters were not comparable to the control group

Moreover, the increased apoptosis of type II AECs in IPF patients can directly cause alveolar collapse, thus accelerating the progression of pulmonary interstitial fibrosis (101)

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