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In lesioning surgery techniques (pallidotomy and thalamotomy), a small lesion is created in the targeted areas of the brain to disrupt abnormal brain activity (68)

Total spot UV and total skin tone showed continuous improvement in the placebo group until Week 8, but this trend declined at Week 12

The accumulation of itaconate causes a metabolic break by inhibiting the enzymic activity of succinate dehydrogenase

In melanocytes 4-HNE, through adduct formation, alters protein function, contributing to oxidative stress-induced cellular dysfunction, which mainly concerns on the functioning of cellular antioxidant system, acceleration of protein degradation, inhibition of melanocyte proliferation, photoaging processes, but also disruption of the intercellular interactions between melanocytes and keratinocytes 101,102,103