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Smokers in the N-Acetylcysteine group maintained abstinence, reported less craving, and higher positive affect compared to the placebo group. (The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study, Froeliger et al., 2015) Furthermore, NAC possesses anti-inflammatory properties that can diminish smoking-induced oxidative stress and subsequent inflammation in the body

As GDF-15, these effects are reduced with the blockade of activin A receptor in animal models (54)

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Macrophage death and defective inflammation resolution in atherosclerosis