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Fitusiran was developed for the treatment of hemophilia and rare bleeding disorders (RBDs) and functions by inhibiting the expression of antithrombin (AT)

Donsbough AL, Powell S, Waguespack A, Bidner TD, Southern LL

Beyond ADCs, they are also used in peptide-drug conjugates, nucleic acid drug delivery systems (such as siRNA and mRNA), nanomedicine carriers, and prodrug designs, providing critical technological support for precision medicine and cancer therapy

In addition, a recent study demonstrated that cisplatin can synergistically act with the ferroptosis inducer erastin, and the combined use of both drugs was found to enhance antitumour effects when compared with the use of either drug alone ( Gene Technology-Induced Ferroptosis Genes are essential in life processes and can encode proteins involved in various cellular activities