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Description

Isatuximab binds to the CD38 epitope via its gamma heavy chains, inducing cell death through mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) and apoptosis 146,147

combined use could intensify these symptoms, though this is theoretical in the absence of clinical data

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that plays a critical role in cellular metabolism and energy homeostasis