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Ferroptosis, first described in 2012, is an iron-dependent form of regulated cell death characterized by: (1) accumulation of lipid peroxides and reactive oxygen species (ROS), (2) distinct mitochondrial morphology including shrinkage and cristae reduction, and (3) dependence on iron metabolism (Yao et al., 2021)

doi: 10.1038/s41586-018-0701-2 Summary Keywords radiation, nitric oxide synthase (NOS), nitric oxide (NO), 5, 6, 7, 8-tetrahydrobiopterin (BH4), radiosensitivity Citation Feng Y, Feng Y, Gu L, Liu P, Cao J and Zhang S (2021) The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil

Longer cycles are an indicator that ovulation is not occurring regularly, which can make conception difficult