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1 Introduction The tumor suppressor protein p53 is often regarded as the gatekeeper of the cell because it is essential for stabilizing the cellular genome ( TP53 , leading to inappropriate activity of wild-type p53 and unrestrained tumor progression ( In the past, apoptosis was regarded as the primary cell death mechanism in conventional cancer treatments

This imbalance of the gut microbiota and continued exposure of the colonic epithelial cells to urea is harmful to intestinal epithelial barrier function as it aids the disruption of the mucus layer and lowers the expression of tight junction proteins (Vaziri et al., 2013

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coli , characterized by diminished energy metabolism, inhibition of cell membrane and wall synthesis, and a weakened stress response and antioxidant capacity