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Dimethyl itaconate activates innate immune defenses, maintains inflammatory homeostasis, activates STAT3 and autophagy, and exhibits strong antimycobacterial properties in both macrophages and in vivo models [102]

Notably, injection site discomfort with GHK-Cu tends to be more frequent than with other peptides, due to the copper component

The oral administration of quercetin-loaded microcapsules generated with a pectin/casein polymer attenuated macroscopic damage and edema, reduced neutrophil recruitment, and reduced levels of IL-1 and IL-33 in the colon tissues of mice with acetic acid-induced colitis (68)

Real-time qPCR was performed using an Applied Biosystems QuantStudio 12 K Flex real time PCR system (Thermo Fisher Scientific, San Jose, CA, USA) with THUNDERBIRD SYBR qPCR Mix (Toyobo), 6 pmol of primers, and aliquots of cDNA