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Description

Sorafenib causes the production of P62, which inhibits NRF2 degradation and promotes the inactivation of KEAP1, followed by the activation of heme oxygenase-1 (HO-1), quinone oxidoreductase-1, and ferritin heavy chain-1, which enhances NRF2 nuclear localization

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This group was established solely to obtain basal values

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DOI: Published online: June 9, 2025 1 Department of Gastroenterology, Mater Hospital Brisbane, Brisbane, Australia 2 Mater Research Institute, The University of Queensland, South Brisbane, Australia Correspondence to Jakob Begun, Department of Gastroenterology, Mater Hospital Brisbane, Raymond Terrace, South Brisbane, QLD 4101, Australia

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L.AskariB.KramerF.BarnhartS.Vivekanandan-GiriA.PennathurS.et al (2011)

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