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4.3 Effect of cognitive effort and sustained cognitive effort on GSH levels The cognitive effort (or task performance) per se did not have any significant effect on GSH levels in either region or either age group

The negligible increment of ascorbate-glutathione content, ascorbate-glutathione redox and ascorbate-glutathione cycle enzymes activities and dramatic increment in malondialdehyde (MDA), hydrogen peroxide (H 2 O 2 ) and EL were observed in the sensitive genotype VA15

This creates an immediate antioxidant surge in the blood, but not necessarily inside the cells where glutathione is actually required to function

Furthermore, endothelial cells in the TME activate the expression of the Notch1 receptor (N1ICD) and facilitate peritoneal metastasis