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In recent years, many key molecular mechanisms of ferroptosis have been identified, including GPX4-GSH, ferroptosis-suppressor-protein 1 (FSP1)-CoQ 10 , GTP cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH 4 ), dihydroorotate dehydrogenase (DHODH)-CoQ, and FSP1-vitamin K (VK)[8, 17-19] (Figure 1)

ProFLG is synthesized in the granular layer of the epidermis as a polyprotein that contains 1012 repeating domains in humans (Gan et al., 1990) but 20 repeats in the mouse (Rothnagel and Steinert, 1990) and rat (Haydock and Dale, 1990)

J Iraqi National Chem

Prevalence of herbal medicine use and associated factors among pregnant women attending antenatal care at public health facilities in Hossana Town, Southern Ethiopia: facility based cross sectional study