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(2009, 2017) synthesized E2 derivative compounds that rapidly undergo metabolic oxidation and lose their affinity for ERs, limiting their effects ( 6.4 Regenerative medicine approaches Given the complexity of wound healing, particularly in older adults with multiple morbidities, and the progressive, degenerative impact of estrogen deficiency on structural components of skin, optimal healing strategies must be able to induce regenerative processes to properly restore skin form and function

Gorantla S, Gorantla G, Saha RN, Singhvi G

the body cant synthesize them endogenously

Among these, the changes in the lipid metabolism of DM were the most obvious, especially glycerophospholipids and unsaturated fatty acids