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Scalp irritation, dryness, and contact dermatitis occur in a subset of users, more commonly with the liquid formulation (which contains propylene glycol) than with foam

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Advanced degenerative conditions severely degenerated cartilage or end-stage joint disease involves tissue that may be beyond repair acceleration

On a deeper level, it seems that vitamin B12's relationship with hair loss or hair growth seems to stem from its necessary function for "DNA synthesis, neurological function, and red blood cell formation," which are all important factors in helping hair cells generate, as well as keeping hair follicles, the base of the hair on the scalp, oxygenated and fed with enough nutrients from digestion as explained further below