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Accordingly, downregulation of ZIP14 and consequent zinc deficiency was observed in a mouse model of alcoholic liver disease (260), Moreover, the lack of ZIP14 upregulation in both IL-6 and iNOS knockout mice clearly suggests that the expression of this zinc transporter is under the control of pro-inflammatory cytokines, namely IL-1 and IL-6 (261, 262)

Toxicokinetics of benzo[a]pyrene in humans: extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing

In rodent models, NAM has been demonstrated to reduce oxidative stress induced by high-fat/high-fructose diets, decrease hepatic cholesterol, TG, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) (Abd-Allah et al