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Ravi Salgia is supported by NIH/National Cancer Institute-R01 award (R01 CA100750 and CA109640), American Cancer Society Award (National), American Lung Association, and Institutional Cancer Research awards from the University of Chicago Cancer Center (with the American Cancer Society) and the V-Foundation (with Geelard Family)

While the regulation of mTORC1 is well-characterized, less is known about the modulators of mTORC2 signaling

Pregnant and nursing people may also have increased needs for this sulphur-containing amino acid

In addition, this pathway indirectly modulates responses to immunotherapy by remodeling the tumor microenvironment, promoting infiltration of tumor-associated macrophages and upregulating immune checkpoint molecules such as PD-L1) (275)