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First documentation of in vivo and in vitro ivermectin resistance in Sarcoptes scabiei

Mechanistically, a variety of SCFA receptors are seen to be expressed in human kidneys, and it was found that olfactory receptor 78 (Olfr78) was expressed mainly on afferent small arterioles (paraglomerular apparatus), which can elevate blood pressure by mediating renin secretion and subsequent vasoconstriction (165)

The CTR is also expressed at the cell surface independently of RAMPs and has a distinct phenotype, exhibiting potent responses to human, and other species of CT peptides, but weak responses to amylin

So you can still inject into thigh, to avoid too much change, but with a shorter thinner needle