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Studies have suggested mechanisms regarding the interaction between the microbiota and the gut-brain axis

In addition to the observed changes of amino acid concentration, mutations of mitochondrial enzymes for amino acid metabolism lead to severe metabolic diseases (Guda et al., 2007)

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In addition, if your deficiency is caused by intestinal problems (such as celiac disease or Crohns disease), the effectiveness of oral supplements may be greatly reduced because the bodys ability to absorb vitamins through the intestines has been impaired