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10.1242/jeb.243407 219 RegoliF.GiulianiM

128 Notably, inhibiting lactylation at K215 and K224 on canopy FGF signaling regulator 3 (CNPY3), a key regulator of protein folding in the endoplasmic reticulum, compromises the formation of the CNPY3 complex with auxiliary molecular chaperones for protein folding and lysosomal transport, thereby affecting its cellular localization and promoting lysosome rupture and pyroptosis in prostate cancer cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Alsharairi N.A

A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl()/H(+) transport cycle