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Accumulated ROS can damage mitochondrial and nuclear DNA, proteins and lipids, further impairing cellular function and viability (Khan et al

Figure 7E ), CDGSH iron sulfur domain-containing protein 1 (CISD1

Wang Y, Zhou S, Yang F, Qi X, Wang X, Guan X, Shen C, Duma N, Vera Aguilera J, Chintakuntlawar A, Price KA, Molina JR, Pagliaro LC, Halfdanarson TR, Grothey A, Markovic SN, Nowakowski GS, Ansell SM, Wang ML Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis

The SI of MFI of ROS-producing PMN ( Supplementary Table 3 ) remained at the same level for 4 h after the immune challenge and showed the significant highest capacity at 9 h pi , followed by a reduction to baseline values until the end of the trial