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Activation of Wnt/-catenin signaling (Wnt ligands binding to Frizzled receptors and LRP5/6 co-receptors) leads to inhibition of the -catenin destruction complex (axin, APC, CK1, GSK3) and subsequent accumulation of -catenin

Sustained systemic oxidative stress may in turn contribute to mitochondrial dysfunction, activation of inflammatory pathways, and dysregulation of neural function, thereby potentially contributing to the symptom burden of ME/CFS (Holden et al., 2020

In medical settings it is usually diluted in normal saline and infused slowly into a vein, with a typical loading dose of 50 mg per kilogram over two to three minutes followed by maintenance doses every six hours or by continuous infusion

Notably, lysophosphatidylcholine acyltransferase 3 (LPCAT3) and acyl-CoA oxidase synthetase long-chain family member 4 (ACSL4) play crucial roles in phospholipid remodelling [48]