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Kennedy SH, Lam RW, McIntyre RS, Tourjman SV, Bhat V, Blier P, et al

In vitro SCFbeta-Trcp1-mediated IkappaBalpha ubiquitination assay for high-throughput screen

When copper levels are excessive, the expression of these metallothioneins changes, which may lead to an ineffective cellular response to oxidative stress, further promoting neuronal damage (131)