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We receive our first gut microbes as babies and our diet and environment adds new ones after that - though environmental exposure can also sometimes harm the gut and reduce the number of microbes

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Because Nrf2 is the upstream gene of GCLC and GCLM, the inhibition of Nrf2 expression by p31-43 will also lead to the inhibition of GCLC expression in cells, which will lead to the decrease of GSH biosynthesis rate in cells, and finally make cells unable to effectively degrade peroxidative stress, which will become more and more serious, leading to cell membrane rupture and apoptosis

Many people turn to supplements to bridge this gap, only to find that not all versions are created equal