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10.1016/j.chb.2014.12.006 166

Additionally, serum levels of short-chain fatty acids (SCFAs), vital bacterial metabolites produced in the colon, are lower in elderly individuals (Sanna et al., 2019)

What's cool is one of our patients who is a nurse

Taken together, during RA, macrophages produce proinflammatory cytokines, chemokines, and free radicals to activate immune and non-immune cells, leading to joint inflammation and destruction