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In this study, rats were fed with a calorie-restrictive KD or a standard diet for four weeks

Secreted Wnt ligands bind Frizzled receptors to regulate diverse processes such as axis patterning, cell division, and cell fate specification

Protein can be added to the nutritional regimen at a slow rate once the patient is able to tolerate protein depending on a combination of different factors, including clinical status, mental status, laboratory derangements and improvement of those