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However, factors such as advanced aging, peripheral inflammation, and cerebral amyloid angiopathy can compromise the integrity of the BBB [182, 183]

D+Q works by inhibiting pro-survival pathways (tyrosine kinases and Bcl-2 family) broadlythese pathways are also present in non-senescent cells, creating off-target effects

Sagasti, "Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival", Journal of Neurogenetics 1-17 (2018)