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It fails because the active molecule is dismantled by the digestive process before it can bind to GHRH receptors in the pituitary

Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism

There are several possible explanations

GHK-Cu has also been reported to lower blood pressure and thus should be carefully administered