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If therapy is unsuccessful, the brain loses as many neurons each hour as it does in approximately 3.6 years of average aging [16]

This rhythm originates from the suprachiasmatic nucleus (SCN), where light exposure transmits neural impulses to the SCN via the retinohypothalamic tract, synchronizing the activity of the SCN and the nocturnal secretion rhythm of melatonin with the 24-h light/dark cycle

Suarez, N

Sirtuin 3 as a regulator of oxidative stress Sirtuin 3 is an NAD + -dependent deacetylase that plays a role in mitochondrial metabolic processes, including energy production, oxidative stress, the tricarboxylic acid cycle, and other processes (Bause et al