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Generally, short-term exposure to low As concentrations increases the activities of these enzymes, whereas chronic exposure usually decreases activity levels ( Shi et al., 2004 )

As a separate response to oxidative stress, studies have suggested that EGFR-mediated NADPH oxidase (NOX) assembly facilitates ROS generation in GBM [82, 83]

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Peptide-targeted cytotoxic peptides Cationic amphipathic peptides with inherent cytotoxicity exhibit advantages: they can attenuate multidrug resistance in tumor cells and present broad-spectrum antitumor activities 47,48