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Also, precise location of PAR1 in neuronal or astrocytic membrane compartments and the current state of neuronal networks seem to influence selectivity of PAR1 to distinct ligands and the recruitment of diverse intracellular signaling pathways by PAR1 (Russo et al., 2009

59 (Suppl 6): 7482

10.1001/jamaneurol.2016.0826 47

Semax + Selank Both are approved pharmaceuticals in Russia and Ukraine, with established clinical use in cognitive enhancement, neuroprotection, and anxiety reduction [10]