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However, studies using subcutaneous melanoma, Lewis lung carcinoma, and colorectal cancer models have shown that cholesterol enriched in the TME induces CD8+ T-cell exhaustion by upregulating the expression of immune checkpoints in an ER stress-XBP1-dependent manner (86)

Zhang Z, Xie Q, Jobe TO, Kau AR, Wang C, Li Y, Qiu B, Wang Q, Mendoza-Cozatl DG, Schroeder JI (2016) Identification of AtOPT4 as a plant glutathione transporter