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Since the adenosine moiety of ATP is largely responsible for the solubilizing effect of ATP as a hydrotrope, it is not surprising that increased adenosine levels in the CSF enhances both glymphatic flow and clearance of wastes in rodent models [319]

Other UPR proteins, p-IRE1 and p-PERK, were also found increased in endometrial cells when they were treated with peritoneal fluid obtained from women with endometriosis (80)

The loop formation stabilized by disulfide bridges can be observed in many different proteins

Nunley PD, Guyer RD, Strenge KB, Patel A, Bae H, Khachatryan A, Park A, Yue J, Khalil J, Stone M: Thirty-six-Month Clinical Outcomes of a Prospective, Controlled, Multicenter Study Evaluating Two-Level Cervical Disc Arthroplasty with a PEEK-on-ceramic Artificial Disc