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Med Res Rev 43(6):18781945 Prochzkov D, Bouov I, Wilhelmov N (2011) Antioxidant and prooxidant properties of flavonoids

10.3892/etm.2020.9097 55 LiuW.ShaoT.TianL.RenZ.GaoL.TangZ.et al (2022b)

However, pretreatment with MK2206 significantly enhanced the amount of ROS-positive AKT-E17K mutant cells upon irradiation ( Figure 1D )

Conclusions Successful oncology development now depends on strategic alignment across three interconnected goals: target validation, disease selection, and dose optimization