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Mitoglitazone and proanthocyanidin co-treated (Mito + Pro) group: mice in this group received both treatments of mitoglitazone and proanthocyanidin orally daily for 12 weeks with the same doses parallel with MASH induction protocol

Abstract We investigated the longstanding idea that the onset of psychotic symptoms in schizophrenia arises from an early phase of glutamate neurotoxicity, possibly related to loss of GABA restraint, oxidative stress or inflammation, that cumulatively results in a later phase of synaptic loss in keeping with magnetic resonance spectroscopy (MRS) evidence of reduced glutamate in schizophrenia, especially in older patients

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