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These pathways include BCL-XL, the cell cycle inhibitor p21, the ephrins EFNB1 and EFNB3, serpin PAI1, the oxygen sensor HIF-1 and phosphatidylinositol 3-kinase-delta (PI3K)

A 2025 cell line study replicated the telomere-lengthening finding and proposed that epithalon may also activate ALT (Alternative Lengthening of Telomeres) pathways in addition to direct telomerase upregulation