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Property Detail Full Name Thymosin Beta-4 active fragment (TB-500) Amino Acids 43 (full T4 sequence) Active Region LKKTETQ (residues 17-23) Molecular Weight ~4,963 Da (full T4) Origin Thymus gland protein, ubiquitous in nucleated cells CAS Number 77591-33-4 (Thymosin Beta-4) FDA Status Not approved WADA Status Prohibited (S2 category) Is TB-500 FDA Approved

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Patients received either pemetrexed 500 mg/m2 intravenously and cisplatin 75 mg/m2 intravenously on Day 1 of each 21-day cycle (n=839) or gemcitabine 1250 mg/m2 intravenously on Days 1 and 8 and cisplatin 75 mg/m2 intravenously on Day 1 of each 21-day cycle (n=830)

J Exp Bot 57:16851696 Schafer FQ, Buettner GR (2001) Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple