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These authors analyzed protein levels in raw plasma from patients whose cognitive status changed from VCD to healed, and vice versa, between recruitment and the six-month follow-up, while the present study evaluated the mRNA levels of these biomarkers in whole blood cultures from volunteers who maintained the same diagnosis between recruitment and the six or 12-month appointment

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J Appl Physiol (1985) 108 , 10691076, (2010)

Adaptive immune cells Th1 and Th17 cells secrete proinflammatory cytokines such as IFN-, TNF-, and IL-17, which facilitate M1 macrophage polarization, leading to tissue damage repair [146]