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5.9 Skin and hair health benefits Skin and hair health are influenced by nutrition, lifestyle, and environmental exposures such as pollution and stress [7, 49]

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The protein Rel-Mtb modulates the intracellular (p)ppGpp content by regulating its synthesis and hydrolysis via an N-terminal hydrolase and synthetase domain ( Rv2583c ( Rel-Mtb ) that subsequently promotes the production of intracellular (p)ppGpp in Mtb ( Rel-Mtb deletion mutant showed a growth defect in liquid media, and the disrupted growth rate was restored when citrate or phospholipid was used as the sole carbon source in vitro ( in vitro nutrient starvation and BALB/c mouse models ( ppx1 or ppk2 deletion mutant strains showed low glycerol-3-phosphate (G3P) and 1-deoxy-xylulose-5-phosphate expression levels in bacterial cells, suggesting downregulated G3P synthesis pathway ( ppk2 and ppx1 deletion mutant increased susceptibility to plumbagin and meropenem, and clofazimine, respectively ( in vivo

Pollard C, Nguyen TP, Ng SP, Frank SJ, Garden AS, Gunn GB, Fuller CD, Beadle BM, Morrison WH, Shah SJ, Wang H, Tung S, Wang C, Ginsberg LD, Zafereo ME, Sturgis EM, Su SY, Hanna EY , Rosenthal DI, Phan J