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however, their overproduction under oxidative stress disturbs the continuity of biological membranes, as well as the basic metabolic processes of cells [110]

Selective hypoxia-responsive mRNA translation can occur by the direct binding of ribosomes to internal ribosome entry sites (IRES) encoded within the 5-untranslated region (UTR) of mRNAs, which allows specific mRNAs to bypass the requirement for eIF4F formation at the 5 UTR cap structure 53,54 (Figure 2)

Borthakur G, Tallman MS, Ofran Y, Foran J, Uy G, DiPersio J, Nagler A, Rowe J, Showel MM, Altman JK, Peled A, Abraham M, Pereg Y, Vainstein A, Oberkovitz G, Lustig TM, Brawer S, Bohana-Kashtan O, Cortes JE, Andreeff M

Improving the nutritive value of rice seeds: elevation of cysteine and methionine contents in rice plants by ectopic expression of a bacterial serine acetyltransferase