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(310) found cycles of repeated low dose TLR7/8 agonist injection within 24h with intervals every five days, compared to one high dose injection every three days, significantly suppressed tumor growth in a mouse model (310), indicating the potential of circumventing TLR tolerance by adjusting treatment dose and time

Mak AL, Augustijn QJJ, Heymann CJF, Havik S, Verdoes X, Rios-Morales M, Bosmans LA, Verheij J, Meijnikman AS, de Jonge PA, et al

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compared with maternal blood, especially in NAC-treated moderate IPTB cases