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also found that mutations in SPOCK2 and CHST3 potentially contribute to disc generation and general back pain in a study of 509,000 European individuals (Freidin et al., 2019)

This important non-enzymatic antioxidant can act not only as an independent oxidant scavenger but it can also work with glutathione peroxidase to remove hydrogen peroxide (an oxidant) from the cell

Regarding cell proliferation, these natural compounds can interfere with the activity of cell cycle regulatory proteins and induce cell cycle arrest

They found that the levels of peroxidase and superoxide dismutase enzymes increased, but catalase enzyme activity decreased