Although the drug met its primary endpoint of achieving a statistically significant weight reduction compared to placebo, the results fell short of the 25% weight loss target that Novo had been pitching to investors
This article compares what is actually documented in the peer-reviewed record for each, states each compounds regulatory reality plainly, and is explicit about the single most important honesty point: no published head-to-head trial has ever compared cagrilintide directly against retatrutide
The FDA's staff reviewers last month said there is little evidence to support the safety and effectiveness of these peptides for their intended uses and flagged a lack of adequate human clinical trials, in contrast to Kennedy's public support
MCT1 is a low affinity, high capacity transporter that has been shown to transport unbranched aliphatic monocarboxylates such as acetate and proprionate and substituted monocarboxylates pyruvate, lactate, acetoacetate and -hydroxybutyrate, with the m values for pyruvate and lactate about 0.7 and 3-5 mM, respectively (Halestrap and Meredith 2004)
