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Because vitamin B12 has action at the cellular level and is in charge of multiple pathways where a deficiency may lead to the subjective feeling of fatigue or low energy

JAMA, 315 (5), 510-511

Am J Pathol 172(2):486494 Khan KA et al (2017) Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface