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According to NICE guidance and standard UK clinical practice, patients with confirmed B12 deficiency and neurological symptoms typically require initial treatment with hydroxocobalamin injections

278 More importantly, p53 can adjust gluconeogenesis, glycolysis, and glucose uptake to affect glucose metabolism in peripheral tissues

LC/ESI-MS analysis of TAGS was performed on a Dionex HPLC system (utilizing the Chromeleon software), consisting of a Dionex UltiMate 3000 mobile phase pump, equipped with an UltiMate 3000 degassing unit and UltiMate 3000 autosampler (sampler chamber temperature was set at 4 C)

Severe adverse event (AE) beyond grade 3 was 12.9%, AE of Grade 5 (hemoptysis, pneumonitis, variceal bleeding, duodenal ulcer perforation, autoimmune hepatitis) was 3.1%